Premium
DRESS‐syndrome on sulfasalazine and naproxen treatment for juvenile idiopathic arthritis and reactivation of human herpevirus 6 in an 11‐year‐old caucasian boy
Author(s) -
Piñana E.,
Lei S. H.,
Merino R.,
Melgosa M.,
De La Vega R.,
GonzalesObeso E.,
Ramírez E.,
Borobia A.,
Carcas A.
Publication year - 2010
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2009.01081.x
Subject(s) - sulfasalazine , medicine , eosinophilia , rash , maculopapular rash , dermatology , arthritis , juvenile rheumatoid arthritis , naproxen , surgery , disease , pathology , alternative medicine , ulcerative colitis
Summary DRESS‐syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a severe drug‐induced hypersensitivity syndrome characterized by diffuse maculopapular rash, lymphadenopathy, multivisceral involvement, eosinophilia and atypical lymphocytes with a mortality rate of 10–40% (Seminars in Cutaneous Medicine and Surgery, 1, 250). It is described in adults treated with aromatic antiepileptics and less frequently with sulphonamides, and non‐steroidal anti‐inflammatory drugs (Clinics in Dermatology, 23, 171; Pediatrics, 108, 485). We report on an 11‐year‐old Caucasian boy hospitalized with a skin eruption, lymphadenopathy, acute hepatitis, renal tubular involvement, haematological abnormalities and human‐herpevirus‐6 reactivation, treated with sulfasalazine and naproxen for juvenile idiopathic arthritis (JIA). This is the first report in children with rheumatic disease and highlights the possibility of sulfasalazine and naproxen‐induced‐DRESS‐syndrome in children with JIA.