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Hepatotoxicity of alpha‐methyldopa in pregnancy
Author(s) -
Slim R.,
Salem C. Ben,
Hmouda H.,
Bouraoui K.
Publication year - 2010
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2009.01078.x
Subject(s) - methyldopa , pregnancy , medicine , hepatitis , alpha (finance) , obstetrics , drugs in pregnancy , drug , pharmacology , fetus , surgery , blood pressure , construct validity , genetics , patient satisfaction , biology
Summary Alpha‐methyldopa is one of the most widely prescribed antihypertensive agents used during pregnancy. Despite its known potential hepatotoxicity, there have been only a few reports describing hepatotoxicity with the use of this drug during pregnancy. We report here a new case of acute hepatitis in a pregnant woman related to the use of alpha‐methyldopa, and briefly review the literature on alpha‐methyldopa‐induced hepatotoxicity in pregnancy.