Premium
Multiple drug interactions – induced serotonin syndrome: a case report
Author(s) -
Montané E.,
Barriocanal A.,
Isern I.,
Parajon T.,
Costa J.
Publication year - 2009
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2009.01023.x
Subject(s) - serotonin syndrome , serotonergic , antidepressant , serotonin , serotonin uptake inhibitors , pharmacology , reuptake inhibitor , drug , medicine , serotonin reuptake inhibitor , drug interaction , pharmacodynamics , citalopram , fluoxetine , pharmacokinetics , psychiatry , anxiety , receptor
Summary Serotonin syndrome is a potentially life‐threatening disorder of excessive serotoninergic activity often due to drug interactions. We report a case of serotonin syndrome induced by pharmacokinetic and pharmacodynamic interactions between three different selective serotonin‐reuptake inhibitors (SSRI) and possibly ciprofloxacin. Extreme caution is necessary in patients treated with serotonin‐reuptake inhibitors who need to be switched to another antidepressant or when they require the addition of concomitant drugs, especially serotoninergic drugs and isoenzimes of cytochrome P450 inhibitors.