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Amphotericin B removal by plasma exchange
Author(s) -
Lew S. Q.
Publication year - 2009
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2008.00964.x
Subject(s) - amphotericin b , medicine , pharmacology , intensive care medicine , therapeutic plasma exchange , surgery , antifungal , dermatology
Summary This case report adds pharmacokinetic knowledge regarding amphotericin B. Amphotericin B is highly protein bound. Plasma exchange removes 50–75% of a substance in plasma within 1–2 h, corresponding to an elimination half‐life of 30–40 min. Amphotericin B reduction ratio by plasma exchange was 40% in this patient who had both liver and renal failure.