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Lack of association between the −759C/T polymorphism of the 5‐HT2 C receptor gene and olanzapine‐induced weight gain among Korean schizophrenic patients
Author(s) -
Park Y.M.,
Cho J.H.,
Kang S.G.,
Choi J.E.,
Lee S.H.,
Kim L.,
Lee H.J.
Publication year - 2008
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2008.00872.x
Subject(s) - olanzapine , 5 ht2c receptor , polymorphism (computer science) , weight gain , association (psychology) , medicine , genetics , schizophrenia (object oriented programming) , allele , psychology , endocrinology , gene , receptor , psychiatry , biology , body weight , 5 ht receptor , psychotherapist , serotonin
Summary Background: Weight gain can be an adverse effect of antipsychotics that significantly affects long‐term health and treatment compliance. Many reports have suggested that the 5‐HT2C receptor gene (HTR2C) is related to appetite and eating behaviours associated with body weight change. We hypothesized that there was a relationship between the HTR2C −759C/T polymorphism and olanzapine‐induced weight gain. Method: Seventy‐nine Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long‐term treatment for at least 3 months. We controlled the use of drugs other than olanzapine except benzodiazepines and anticholinergics. Genotyping for the HTR2C −759C/T polymorphism was performed on all participants. Result: We found that long‐term treatment with olanzapine resulted in mean gains in weight and BMI of 5·2 kg and 1·93 kg/m 2 , respectively. However, body weight changes from baseline to the study endpoint were not significantly associated with genotypes. The frequency of the T allele did not differ significantly between subjects with weight gains below and above a clinically significant cutoff, defined as 7% relative to baseline (χ 2 = 0·213, P = 0·445), indicating that the T allele had no protective effect against olanzapine‐induced weight gain. Discussion and conclusion: The findings from this study do not support the presence of a relationship between the –759C/T polymorphism of the HTR2C gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment.