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Pharmacokinetics of quinine and its metabolites in pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria
Author(s) -
Abdelrahim I. I.,
Adam I.,
Elghazali G.,
Gustafsson L. L.,
Elbashir M. I.,
Mirghani R. A.
Publication year - 2007
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2007.00788.x
Subject(s) - quinine , plasmodium falciparum , malaria , pharmacokinetics , medicine , pharmacology , obstetrics , immunology
Summary Objectives: The study was conducted in New Halfa teaching hospital, eastern Sudan to investigate the pharmacokinetics of quinine in pregnant Sudanese women. Methods: Sixteen (eight pregnant and eight non‐pregnant) Sudanese women infected with Plasmodium falciparum malaria were given a single dose of quinine hydrochloride (10 mg/kg body weight) as intravenous infusion over 2 h. The women were treated with intramuscular artemether. Plasma was collected before quinine administration and up to 72 h thereafter. These were analysed for quinine and its metabolites, 3‐hydroxyquinine, (10 R )‐10,11‐dihydroxyquinine and (10 S )‐10,11‐dihydroxyquinine using high‐performance liquid chromatography. Results: The two groups were well matched in their basic characteristics. There was no significant difference in the mean maximum plasma concentration attained ( C max ), the mean time at which C max was attained, the elimination half‐life ( t 1/2 ) and the total area under the plasma concentration vs. time curve (AUC) of quinine and its metabolites between the pregnant in non‐pregnant women. Conclusion: There was no significant difference in quinine metabolism between pregnant and non‐pregnant women and there is no need to adjust quinine dose when treating pregnant women.