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Allergic contact angioedema to benzoyl peroxide
Author(s) -
Minciullo P. L.,
Patafi M.,
Giannetto L.,
Ferlazzo B.,
Trombetta D.,
Saija A.,
Gangemi S.
Publication year - 2006
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2006.00738.x
Subject(s) - benzoyl peroxide , acne , angioedema , dermatology , patch test , medicine , allergen , allergy , hypersensitivity reaction , contact dermatitis , contact allergy , chemistry , immunology , organic chemistry , polymerization , polymer
Summary Benzoyl peroxide (BP) is commonly used for topical acne treatment and has long been known to be a weak allergen and a strong irritant. We report a case of a 26‐year‐old woman, who presented with an itchy erythematous reaction and strong oedema localized to the face. Two weeks before angioedema, the patient had started a new topical treatment with a gel containing 10% BP for acne. She was patch tested to European Standard Series, including BP 1% in white petrolatum, and to the 10% BP‐containing gel previously used by herself, showing positivity on day 2 to BP 1% and to the 10% BP‐containing gel. Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch‐test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.