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Can childhood trauma predict response to topiramate in borderline personality disorder?
Author(s) -
Do PradoLima P. A. S.,
Kristensen C. H.,
Bacaltchuck J.
Publication year - 2006
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2006.00716.x
Subject(s) - topiramate , psychology , personality , borderline personality disorder , abandonment (legal) , extinction (optical mineralogy) , clinical psychology , psychiatry , antisocial personality disorder , developmental psychology , epilepsy , medicine , poison control , injury prevention , medical emergency , social psychology , paleontology , political science , law , biology
Summary We report on a woman with borderline personality disorder and a history of childhood trauma that showed significant clinical response with low dosage of topiramate. We propose that topiramate changed some of the main features of this disorder, such as catastrophic reaction to real or imaginary abandonment or rejection, improving adaptive functioning. We hypothesize that topiramate might facilitate memory extinction, therefore decreasing emotional and behavioural reactivity.