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Stability of doxorubicin combined with Radioselectan ® , a contrast agent, for chemoembolization
Author(s) -
Chiadmi F.,
Daroso J.,
Schlatter J.,
Cisternino S.,
Ratiney R.,
Fontan J. E.
Publication year - 2005
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2005.00654.x
Subject(s) - doxorubicin , chemistry , chromatography , detection limit , surgery , chemotherapy , medicine
Summary Objective: To assess the stability of doxorubicin combined with Radioselectan ® . Methods: Solutions of doxorubicin 5 mg/mL were prepared from commercially available 50 mg powder with 10 mL of Radioselectan ® . They were stored in glass syringes at 4, 25 and 45 °C. The concentrations of doxorubicin were determined using a stability‐indicating high‐performance liquid chromatography method. The initial and final pHs of solutions were compared. The times ( t 90 ) needed for doxorubicin to fall to 90% of its initial concentration were calculated by a linear regression analysis. Results: The t 90 [95% confidence limits] were 79 [75–83], 56 [53–59] and 22 [21–23] hours for the solutions stored at 4, 25 and 40 °C respectively. The initial pH of the solutions stored at 4, 25 and 40 °C were 6·52, 6·50 and 6·51 respectively. The final pH of solutions stored at 25 and 40 °C decreased significantly by 0·3 and 0·9 respectively. No change of pH solution stored at 4 °C was observed. Conclusion: Doxorubicin combined with Radioselectan ® stored at room temperature is stable for 48 h.