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Isoniazid acetylation phenotyping in Saudi Arabs
Author(s) -
Matar K. M.,
Mayet A. Y.,
Ayoola E. A.,
Bawazir S. A.,
AlFaleh F. Z.,
AlWazzan A.
Publication year - 2004
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2004.00588.x
Subject(s) - isoniazid , acetylation , allele frequency , phenotype , allele , pharmacogenetics , medicine , pharmacology , distribution (mathematics) , genetics , biology , genotype , gene , pathology , tuberculosis , mathematics , mathematical analysis
Summary Aims: The present study is designed to investigate the acetylator status in Saudi Arabs. Methods: Isoniazid (INH) acetylation phenotyping was studied in 136 Saudi Arabs in Riyadh, Saudi Arabia, using a single plasma sample taken 3 h post‐INH oral dose of 200 mg. Metabolic ratio (MR) of plasma acetyl‐INH (Ac‐INH) to INH was used to determine the acetylation phenotype. Results: The MR had a bimodal distribution with an antimode of 1·0. The frequency distribution of slow acetylators (MR < 1·0) was 94·9% ( n = 129). Using Hardy–Weinberg Law, the gene frequency ( q ) of the recessive allele determining slow acetylator phenotype was found to be 0·97. Conclusion: INH phenotyping suggests a high frequency of slow acetylators among Saudi Arabs. There was no association between the MR of plasma Ac‐INH/INH and age or gender.