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Compatibility of a commercially available low–density polyethylene eye–drop container with antimicrobial preservatives and potassium ascorbate
Author(s) -
Barnes A. R.
Publication year - 1995
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1995.tb00708.x
Subject(s) - antimicrobial , preservative , potassium sorbate , potassium , eye drop , compatibility (geochemistry) , drop (telecommunication) , chemistry , food science , materials science , medicine , pharmacology , organic chemistry , computer science , composite material , telecommunications , sugar
SUMMARY The compatibility of the 7 ml size of Steri–Dropper, a commercially available low–density polyethylene sterile eye–drop container, was studied for use with solutions containing the antimicrobial preservatives benzalkonium chloride and phenylmercuric acetate. For benzalkonium chloride, there was no difference between the Steri–Dropper and the glass eye–drop bottles throughout the study period of 84 days. However, there was less phenylmercuric acetate present in the Steri–Dropper compared to the glass containers by the end of the study. The suitability of the Steri–Dropper bottle was also studied for use with potassium ascorbate eye drops; these degraded more in Steri–Dropper compared to glass containers and a yellow discoloration of the product was also seen in these containers. The Steri–Dropper bottle is therefore potentially compatible with dispensed formulations containing benzalkonium chloride and, for short periods only, with phenylmercuric acetate. The container would only be suitable for use with oxygen–sensitive drugs for short periods. Further validation of the suitability of the Steri–Dropper bottle would be required for use with any specific formulation.