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Stability of vancomycin in plastic syringes measured by high–performance liquid chromatography
Author(s) -
Wood M. J.,
Lund R.,
Beavan M.
Publication year - 1995
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1995.tb00705.x
Subject(s) - vancomycin , chromatography , high performance liquid chromatography , chemistry , staphylococcus aureus , bacteria , biology , genetics
SUMMARY The shelf–life of vancomycin in infusion fluids was studied using high–performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in waterfor–injections BP at 25°C and stored in plastic syringes (Becton Dickinson Plastipak (three–piece) and B. Braun Medical Injekt (two–piece)). In sodium chloride solution (0 9%; pH 5 4) it was stable for 62 and 34 days, while in dextrose solution (5%; pH 4 2) it was stable for 55 and 33 days, respectively, at the same temperature. At 4°C vancomycin was stable in all three infusion fluids and both types of syringe for at least 84 days.