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Dental properties of antiseptic throat lozenges formulated with sugars or Lycasin
Author(s) -
Grenby T. H.
Publication year - 1995
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1995.tb00655.x
Subject(s) - lozenge , throat , chemistry , antiseptic , mouth rinse , dentistry , food science , sucrose , hydroxylapatite , biochemistry , medicine , organic chemistry , surgery , enzyme , archaeology , history
SUMMARY Thirteen different formulations of throat lozenges were examined for their acidity, demineralizing action on hydroxylapatite, and fermentability by human dental plaque micro–organisms. Their flavouring acids gave them low pH values in the range 2 6‐3 7, leading to the dissolution of calcium and phosphorus from hydroxylapatite. The combination of antiseptics and flavouring acids in the lozenges inhibited microbial growth and metabolism. In the absence of any antiseptics and flavouring acids, the growth and metabolic activity of cultures of plaque micro–organisms were significantly greater on sucrose + glucose lozenges than on a new Lycasin formulation.