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Prolonged bleeding time during ciprofloxacin therapy
Author(s) -
Pilmore H. L.,
Walker R. J.
Publication year - 1995
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1995.tb00625.x
Subject(s) - ciprofloxacin , medicine , nausea , quinolone , side effect (computer science) , bleeding time , antibiotics , coagulation , anesthesia , surgery , platelet aggregation , platelet , computer science , microbiology and biotechnology , biology , programming language
SUMMARY Ciprofloxacin is a broad spectum quinolone antibiotic. Side effects reported include nausea and other gastrointestinal symptoms; skin and musculoskeletal side effects may also occur. No bleeding abnormalities or alteration in coagulation have been documented. We report a case where ciprofloxacin appeared to contribute to an idiosyncratic prolongation of bleeding time although a rechallenge 8 months later did not reproduce the effect. Moreover, subsequent investigation of the influence of ciprofloxacin on bleeding parameters in 10 healthy volunteers demonstrated no alterations in bleeding parameters.