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Shelf–life determination of prostaglandin El injections
Author(s) -
Shulman N. H.,
Fyfe R. K.
Publication year - 1995
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1995.tb00624.x
Subject(s) - chromatography , high performance liquid chromatography , prostaglandin , saline , chemistry , shelf life , alcohol , medicine , anesthesia , food science , biochemistry
SUMMARY A rapid stability indicating assay for the determination of prostaglandin El (PGEl) in pharmaceuticals was developed using High Pressure Liquid Chromatography (HPLC). A solution of 20 μg/ml PGEl in 4% alcohol and 0–9% saline has an activation energy of 18 683 cal/mol and the predicted shelf–lives were: at 4°C t 95 = 51‐8 days and t 90 = 106‐5 days and at 25°C t 95 = 4–8 days and t 90 = 9‐8 days.