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Effects of water deprivation for 48 hours on the pharmacokinetics and pharmacodynamics of furosemide in rats
Author(s) -
Kang M. J.,
Yoon W. H.,
Kim O. N.,
Lee M. G.
Publication year - 1995
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1995.tb00620.x
Subject(s) - furosemide , pharmacokinetics , diuretic , pharmacodynamics , oral administration , pharmacology , medicine , sodium , excretion , urine , diuresis , body weight , potassium , kidney , endocrinology , chemistry , organic chemistry
SUMMARY The effects of water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of furosemide were examined after intravenous, 8 mg/kg body weight, and oral administration, 16 mg/kg body weight, of furosemide to control and water deprived rats. After i.v. administration, the total body and nonrenal clearances decreased significantly in water–deprived rats. The urine output, urinary excretion of sodium, potassium and chloride based on grams of kidney weight, and the diuretic, natriuretic and chloruretic efficiencies decreased significantly in waterdeprived rats after both intravenous and oral administration of furosemide, suggesting that the dose of furosemide for water–deprived patients may require modification.