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The influence of ciprofloxacin on the pharmacokinetics and pharmacodynamics of a single dose of temazepam in the young and elderly
Author(s) -
Farhad Kamali,
Barbara Herd,
C. A. Edwards,
E. Nicholson,
Hilary Wynne
Publication year - 1994
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1994.tb01120.x
Subject(s) - pharmacokinetics , pharmacology , pharmacodynamics , theophylline , medicine , ciprofloxacin , quinolone , chemistry , antibiotics , biochemistry
The effect of pretreatment with a 4-day course of ciprofloxacin (500 mg twice daily) on the pharmacokinetics and pharmacodynamics of a single oral dose of temazepam (10 mg) was investigated in 12 healthy young and nine elderly patient volunteers in a crossover design study. Temazepam clearance was lower in the elderly than in the young, but this difference was not statistically significant. Ciprofloxacin had no significant effect on temazepam pharmacokinetics or pharmacodynamics in either age group.