Premium
Stability of ciprofloxacin in 5% dextrose and normal saline injections
Author(s) -
Mathew M.,
Gupta V. Das,
Zerai T.
Publication year - 1994
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1994.tb00684.x
Subject(s) - saline , ciprofloxacin , chromatography , chemical stability , anesthesia , medicine , chemistry , surgery , antibiotics , organic chemistry , biochemistry
SUMMARY The stability of ciprofloxacin in 5% dextrose and normal saline i.v. admixtures have been determined using a stability‐indicating high performance liquid chromatographic assay method reported in the literature. The solutions were stored in plastic bags, a procedure being used in hospitals for in or out‐patient therapy. The solutions were stable for at least 3 months when stored at room or refrigerator temperatures. They remained clear throughout the study and their pH values did not change. The expiry date recommended by the manufacturer appears to be very conservative from a chemical viewpoint.