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A comparison of the endotoxin‐retentive abilities of two ‘96‐h’ in‐line intravenous filters
Author(s) -
Richards C.,
Grassby P. F.
Publication year - 1994
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1994.tb00673.x
Subject(s) - filtration (mathematics) , pseudomonas aeruginosa , chromatography , medicine , microbiology and biotechnology , chemistry , pharmacology , bacteria , biology , mathematics , statistics , genetics
SUMMARY The ability of two in‐line intravenous filters, the Pall Intravenous Set Saver Filter ELD96 and the Codan I.V. S SET‐P, to retain endotoxin released by Pseudomonas aeruginosa during filtration of amino‐acid‐based parenteral nutrition (PN) solutions was investigated. When challenged with 10 8 cells of P. aeruginosa during simulated clinical PN infusion, the Pall ELD96 was shown to be capable of providing an effluent free of detectable endotoxin (>0–3125 EUE/ml). In contrast, the Codan I.V. S SET‐P allowed significant amounts of endotoxin to pass through.