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Dissolution testing of tablet and capsule dosage forms
Author(s) -
Mehta A. C.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00880.x
Subject(s) - dissolution , bioavailability , dissolution testing , dosage form , bioequivalence , capsule , in vivo , pharmacology , drug , chromatography , chemistry , medicine , microbiology and biotechnology , biopharmaceutics classification system , biology , botany
SUMMARY Dissolution testing has become the major in vitro test for determining the quality of oral dosage forms. Although correlation between in vitro test and in vivo bioavailability of a drug may not be automatically assumed, it is nevertheless widely accepted that failure of a product to meet the dissolution requirement may be indicative of a potential bioavailability problem. In dissolution testing modern analytical techniques play an important part. This paper discusses the present status of dissolution tests for tablets and capsules and assesses some of the analytical techniques used in such tests.