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Calcium channel blockers and antioxidant levels
Author(s) -
Chen G.,
Wilson R.,
McKillop J. H.,
Smith W. E.,
Walker J. J.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00878.x
Subject(s) - nimodipine , nifedipine , antioxidant , chemistry , pharmacology , calcium channel , superoxide dismutase , calcium , glutathione , lysis , calcium channel blocker , biochemistry , medicine , enzyme , organic chemistry
SUMMARY The aim of this study was to determine in vitro whether calcium channel blockers (nifedipine and nimodipine) exert their antiperoxidative effect by changing the antioxidant levels. Four antioxidant markers in red blood cells were investigated: membrane thiol, lysate thiol, lysate total glutathione and lysate superoxide dismutase. These antioxidant markers were measured after cells were incubated with varying concentrations of nifedipine and nimodipine (1–1000 ng/ml) for different time periods (0–120 min). The results showed that neither nifedipine nor nimodipine significantly increased antioxidant levels. In conclusion, it appears that calcium channel blockers are unable to elevate the levels of the physiological antioxidant agents detected in this in vitro experiment.