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Compatibility of diazepam (Valium®), clorazepate dipotassium salt (Tranxene®) and midazolam hydrochloride (Hypnovel®) with Stedim 6®, a new multilayer polyethylene‐lined film for infusion bags: a comparative study with polyvinyl chloride bags
Author(s) -
Airaudo Ch. B.,
GayteSorbier A.,
Bianchi Ch.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00876.x
Subject(s) - polyvinyl chloride , polyethylene , diazepam , sodium , chemistry , midazolam , hydrochloride , chromatography , anesthesia , medicine , organic chemistry , sedation
SUMMARY The compatibilities of diazepam, clorazepate dipotassium salt and midazolam hydrochloride with Stedim 6® bags have been studied and compared with those observed with PVC bags. Stedim 6 is a new polyethylene‐lined material, composed of several layers, one of which is more air‐impermeable. Whereas the losses of diazepam in PVC bags reached 25 and 28% after 72 h storage in 5% dextrose and 09% sodium chloride solutions, respectively, the extent of sorption in Stedim 6 bags did not exceed 10%. Clorazepate dipotassium salt and midazolam hydrochloride compatibilities with Stedim 6 were excellent and slightly better than with PVC, given that no loss was observed in 5% dextrose and in 09% sodium chloride solutions. The compatibility of midazolam hydrochloride in neutral admixtures was far better with Stedim 6 (18% loss after 72 h) than with PVC (66% loss). Multilayer containers appear to be a convenient solution for the storage of lipophilic drug infusion admixtures.