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Amphotericin B and its delivery by liposomal and lipid formulations
Author(s) -
Gates C.,
Pinney R. J.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00605.x
Subject(s) - amphotericin b , pharmacology , liposome , pharmacokinetics , toxicity , therapeutic index , antifungal , drug , drug delivery , chemistry , medicine , biochemistry , organic chemistry , dermatology
SUMMARY In recent years, new formulations of the original amphotericin B preparation (Fungizone) have been devised in order to overcome toxicity problems that frequently occur. These preparations represent an improved method of drug delivery, with an increased therapeutic index and a decrease in toxicity to mammalian cell membranes. The new formulations have different physico–chemical characteristics and differ in pharmacokinetic parameters. Their effects must be compared with conventional amphotericin B to ascertain potential roles in future antifungal therapy.