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Emulsion stability in total parenteral nutrition mixtures compounded from the fat emulsion ‘Elolipid® 20%’
Author(s) -
Washington C.,
Kerbl S. S. Davis and H.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00602.x
Subject(s) - creaming , emulsion , zeta potential , parenteral nutrition , electrolyte , chromatography , chemistry , coulter counter , coalescence (physics) , fat emulsion , materials science , organic chemistry , medicine , surgery , nanotechnology , electrode , biology , microbiology and biotechnology , astrobiology , nanoparticle
SUMMARY The stability of six total parenteral nutrition (TPN) mixtures, compounded from Leopold Pharma products, were studied for 30 days using a new, proposed, standard stability testing protocol based on droplet counting using the Coulter counter. The mixtures tested were stable for 1–4 weeks, and small variations in the coalescence rate were apparent between mixtures. Visual studies detected only very small amounts of creaming in the mixtures, at the limits of detection. The effect of the various TPN components on the zeta potential of the emulsions was studied. The major factors reducing emulsion zeta potential were found to be the electrolyte level (as Elotrace®) and the amino acid–glucose mixtures Aminomel® 7% G and 10% G. The zeta potentials of the emulsions in the TPN mixtures were also measured and these broadly correlated with the stability of the mixtures.