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Effects of α, β–blocker, arotinolol chloride, on 24–h blood pressure–difference between elderly and younger hypertensive patients
Author(s) -
Kuwajima I.,
Suzuki Y.,
Otsuka K.,
Kawamura H.,
Kuramoto K.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00588.x
Subject(s) - medicine , blood pressure , diastole , ambulatory , ambulatory blood pressure , circadian rhythm , essential hypertension , cardiology
SUMMARY To assess the effect of age on the circadian blood pressure (BP) after an α, β–adrenergic blocker, the ambulatory BP was measured before and after arotinolol chloride administration in nine younger (mean age 491 years) and 14 older (721 years) patients with essential hypertension. After a 4–week control period, arotinolol chloride was administered twice daily (08:00 and 20:00 hours) for 8 weeks and the ambulatory BP was measured non–invasively at the end of the control and treatment period. Arotinolol significantly reduced the daytime systolic BP from 1523 to 1409 mmHg (P < 005) and night–time systolic BP from 1373 to 1223 mmHg (P < 001) in the younger hypertensive patients. In contrast, in the older group, the night–time systolic BP did not show a significant change, although the daytime systolic BP was significantly reduced from 1550 to 1422 mmHg (P < 002). Diastolic BP in both groups was significantly reduced by arotinolol during the day and night. Night–time reduction of BP was significantly less in the older group (– 86 vs –151 mmHg for the systolic pressure P < 001; – 58 vs –98 mmHg for the diastolic pressure P <001).