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Physicochemical properties of parenteral fat emulsions containing 20% triglyceride; Intralipid and Ivelip
Author(s) -
Washington C.,
Koosha F.,
Davis S. S.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00578.x
Subject(s) - fat emulsion , parenteral nutrition , triglyceride , emulsion , chemistry , medicine , chromatography , biochemistry , cholesterol
SUMMARY The paper describes an in–depth study of the parenteral fat emulsions, Intralipid 20% and Ivelip 20%. A large number of emulsion samples from separate containers and batches was sampled. The parameters measured were droplet size (both by photon correlation and laser diffraction), pH and zeta potential. These parameters were re–measured after the emulsions were subjected to a number of accelerated stability tests (freeze–thaw cycling, autoclaving and shaking). The results demonstrate that although the Intralipid is stable, it can show some variability between separate batches. The stability of Ivelip is high, and the variability between separate batches is extremely low.