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Detection and determination of interfering 5–hydroxymethylfurfural in the analysis of caramel–coloured pharmaceutical syrups
Author(s) -
Hewala I. I.,
Zoweil M.,
Onsi S. M.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00566.x
Subject(s) - chemistry , absorbance , chromatography , detection limit , 5 hydroxymethylfurfural , hydroxymethylfurfural , sodium borohydride , active ingredient , organic chemistry , pharmacology , catalysis , medicine , furfural
SUMMARY A comparison between different caramels described for use in the pharmaceutical industry is presented. An interfering substance, 5–hydroxymethylfurfural (5–HMF), was detected in some caramels. Conditions and proofs for the formation of 5–HMF are presented. Interference by 5–HMF during the analysis of the active drugs and the possibility of interaction with the active drugs during the shelf–life of the drug formulation are discussed. A limit test for 5–HMF in caramel was developed. The test depends on measuring the difference in absorbance between two equimolar solutions of caramel, one of which contains sodium borohydride. The test is sensitive and selective for the detection and determination of trace amounts of 5–HMF without interference from the brown products of caramel.