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Drug–induced thrombocytosis
Author(s) -
Frye J. L.,
Thompson D. F.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00565.x
Subject(s) - thrombocytosis , platelet , medicine , drug , pharmacology , gastroenterology
SUMMARY Thrombocytosis is generally defined as platelet counts greater than 400, 000/mm 3 . Thrombocytosis can be either primary or secondary. Adrenalin was one of the first drugs noticed to cause platelet elevations, probably due to demargi–nation of platelets in the pulmonary vasculature. Vinca alkaloids have the most convincing data to show that they can induce thrombocytosis through their thrombocyte–stimulating properties. Miconazole has been implicated in causing thrombocytosis and has a documented case validated by drug re–challenge. Iron, predictably, can cause a transient thrombocytosis. The β–actam antibiotic data are very difficult to interpret due to the possibility of an acute–phase reaction in an infected patient being the cause of the thrombocytosis.