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Effect of oral activated charcoal on propranolol pharmacokinetics following intravenous administration to rabbits
Author(s) -
Al–Meshal M. A.,
El–Sayed Y. M.,
Al–Angary A. A.,
Al–Dardiri M. M.
Publication year - 1993
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1993.tb00564.x
Subject(s) - pharmacokinetics , propranolol , activated charcoal , medicine , oral administration , anesthesia , pharmacology , chemistry , organic chemistry , adsorption
SUMMARY The pharmacokinetics of propranolol following intravenous administration (1 mg/kg), with and without treatment with oral activated charcoal, was investigated in rabbits. In charcoal–treated rabbits a significant reduction in propranolol serum concentrations was observed compared to control animals. Charcoal treatment significantly reduced the halflife of elimination (16–6%) and the mean residence time (19%) of propranolol. A 17% increase in the systemic clearance and a 14% decrease in AUC were also noted. Charcoal administration did not significantly alter the volume of distribution (V c V erea and V 55 ) or the apparent distribution half–life. A two–compartment model adequately described propranolol in control and treated rabbits. The results indicate that administration of oral activated charcoal enhances the systemic elimination of propranolol. This is presumably mediated by interruption of the enterohepatic circulation of propranolol by activated charcoal.