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Stability of cisplatin in ethylene vinylacetate portable infusion‐pump reservoirs
Author(s) -
Rochard E.,
Barthes D.,
Courtois P.
Publication year - 1992
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1992.tb01310.x
Subject(s) - cisplatin , ethylene , stability (learning theory) , chemistry , chromatography , surgery , medicine , computer science , organic chemistry , chemotherapy , catalysis , machine learning
SUMMARY The stability of cisplatin in admixture stored in portable pump reservoirs was investigated. Admixtures containing 0.9 or 0.5 mg/ml cisplatin in 0.9% sodium chloride injection were placed in 80‐ml ethylene vinylacetate (EVA) drug reservoirs protected from light and 1‐ml quantities were withdrawn immediately after preparation and after storage for 1, 2, 3, 4, 7, 14, 28 days at +22 or + 35°C. Three samples for each condition from each admixture were tested for drug concentration using a stability‐indicating high‐performance liquid chromatographic method. No colour change or precipitation was observed, and pH values were stable for the duration of the study. Loss of water through the reservoirs was substantial only when stored at + 35°C for 28 days. Cisplatin is stable in the infusion fluid used for 28 days under all the storage conditions considered.