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Stabilization by ethylenediaminetetraacetic acid of amide and other groups in drug compounds
Author(s) -
Fogg A. G.,
Summan A. M.
Publication year - 1992
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1992.tb01276.x
Subject(s) - ethylenediaminetetraacetic acid , amide , drug , chemistry , medicine , pharmacology , organic chemistry , chelation
SUMMARY Ethylenediaminetetraacetic acid (EDTA) was shown to be effective in stabilizing pharmaceutical compounds, which contain acetamido groups, from degradation by light, e.g. paracetamol. Its addition is particularly effective in stabilizing such compounds from the action of ascorbic acid in the light or dark. EDTA was also shown to stabilize lignocaine, sulphadiazine and succinylsulpha‐thiazole. Previous studies had shown that EDTA stabilizes the acetamido group present in two synthetic food colouring compounds.