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INFLUENCE OF AGE AND CONCURRENT MEDICATION ON STEADY‐STATE VALPROIC ACID SERUM LEVEL‐DOSE RATIOS IN JAPANESE PAEDIATRIC PATIENTS
Author(s) -
Yukawa E.,
Suzuki A.,
Higuchi S.,
Aoyama T.
Publication year - 1991
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1991.tb00317.x
Subject(s) - valproic acid , medicine , epilepsy , pediatrics , anticonvulsant , age groups , gastroenterology , anesthesia , psychiatry , demography , sociology
Summary The effects of age and co‐medication on steady‐state valproic acid (VPA) level/dose { L/D ) ratios were evaluated retrospectively in 382 paediatric patients. The VPA L/D ratio increased significantly with age up to 15 years of age in patients on monotherapy ( L/D = 0·149 × AGE+ 2·708, n = 192, r = 0·549, P >0·001). In patients taking three or more anti‐epileptic drugs, including VPA, there was no such effect. Associated anti‐epileptic therapy affected the VPA L/D ratio, which was significantly reduced in patients on polytherapy as compared to patients on monotherapy. Therefore, routine monitoring of VPA serum levels would be extremely useful, especially in the paediatric age group, and in patients who require associated anti‐epileptic medication.