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PHARMACOKINETICS OF INTRAVENOUS CAFFEINE IN CRITICALLY ILL PATIENTS
Author(s) -
SánchezAlcaraz A.,
Ibá¯iez P.,
Sangrador G.
Publication year - 1991
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1991.tb00316.x
Subject(s) - pharmacokinetics , caffeine , plasma clearance , volume of distribution , medicine , critically ill , half life , pharmacology , distribution (mathematics) , anesthesia , chemistry , mathematical analysis , mathematics
Summary The pharmacokinetics of intravenous caffeine used to measure liver function were evaluated in 20 critically ill patients. Each patient received a single dose of 3·0mg/kg of caffeine benzoate as a 30‐min i.v. infusion. Caffeine serum concentrations were analysed by an enzyme‐multiplied immunoassay technique (EMIT). Caffeine pharmacokinetics fitted an open one‐compartment model. The mean value for the half‐life ( t 1/2 ) was 9·46 × 4·32 h, the volume of distribution was 0·55 × 0·131/kg, and the plasma clearance ( Cl ) was 0·85 × 0·44 ml/min/kg. The pharmacokinetics parameters of caffeine in critically ill patients compared with normal volunteers were characterized by a reduction in plasma clearance and prolongation in plasma half‐life, whereas the volume of distribution remained unchanged.