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MEASUREMENT OF NORMAL HUMAN AIRWAYS RESPONSE TO β‐ADRENOCEPTOR STIMULATION USING A FORCED OSCILLATION TECHNIQUE
Author(s) -
Lipworth B.J.,
Clark R. A.,
McDevitt D. G.
Publication year - 1991
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1991.tb00302.x
Subject(s) - placebo , salbutamol , confidence interval , medicine , reproducibility , analysis of variance , stimulation , coefficient of variation , respiratory system , forced oscillation , dose–response relationship , anesthesia , mathematics , statistics , asthma , pathology , physics , alternative medicine , nonlinear system , quantum mechanics
Summary The purpose of the present study was to evaluate the responsiveness of normal human airways to β‐adrenoceptor stimulation using a forced oscillation technique. Seven normal volunteers (aged 25±2 year) were studied on three occasions, separated by weekly intervals, using a single‐blind randomized design. On day 1, subjects were given cumulative doses of inhaled salbutamol (100, 200, 500, 1000 μg); and identical placebo was given on the other two visits. Respiratory oscillation impedance ( R os ) was measured at baseline and 15 min after each dose increment. The coefficients of variation ( CV ) for short‐term intra‐individual variability on each placebo day were 7·5 and 9·5, and 9·6% for long‐term variability (measured over all three visits). The 95% confidence values (2SD) for the change in R os required to exclude natural variability were 0·39, 0·50 and 0·53 cmH 2 O ‐1 s, respectively. There was a small fall in R os in response to salbutamol although the mean maximum change (0·46cmH 2 O 1 ‐1 s) was not significant (by ANOVA). Thus, the change in R os (sensitivity) was no greater than the 95% confidence value for natural variability (reproducibility). Regression analysis also showed no evidence of a dose‐response relationship for R os .