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THE STABILITY OF CARBOPLATIN, DIAMORPHINE, 5‐FLUOROURACIL AND MITOZANTRONE INFUSIONS IN AN AMBULATORY PUMP UNDER STORAGE AND PROLONGED ‘IN‐USE’ CONDITIONS
Author(s) -
Northcott M.,
Allsopp M. A.,
Powell H.,
Sewell G. J.
Publication year - 1991
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1991.tb00293.x
Subject(s) - ambulatory , carboplatin , medicine , fluorouracil , anesthesia , chemotherapy , cisplatin
Summary Drug infusions can be exposed for prolonged periods to ‘in‐use’ conditions where the temperature of an infusion in a holster‐worn infusion pump may reach 37°C. In this study, the stability of three cytotoxic drug infusions (carboplatin, 5‐fluorouracil and mitozantrone) and one analgesic infusion (diamorphine HCl) was determined in Parker Micropump medication reservoirs under refrigerated storage and prolonged in‐use conditions. The stability of the three cytotoxic drug infusions was unaffected by 14 days storage at either 4 or 37°C. The diamorphine HCl infusion was stable over 14 days storage at 4°C but under in‐use conditions at 37°C, drug degradation became significant (> 5%) if storage exceeded 7 days.