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INVESTIGATION OF THE EFFECTS OF β‐2 STIMULATION ON FREE FATTY ACIDS IN MAN
Author(s) -
Kendall M. J.,
Clark N. W.,
Haffner C. A.,
Kong J.,
Hughes B. A.
Publication year - 1991
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1991.tb00281.x
Subject(s) - terbutaline , lipolysis , chemistry , oleic acid , stimulation , saline , fatty acid , placebo , agonist , endocrinology , adrenergic agonist , medicine , pharmacology , biochemistry , receptor , alternative medicine , adipose tissue , pathology , asthma
Summary In this study we present evidence that lipolysis in man is under β‐2 adrenergic control and that β‐2 stimulation produces a characteristic profile of individual free fatty acid (FFA) release. Twelve healthy volunteers received infusions of placebo (N Saline), terbutaline (a selective β‐2 agonist) and dilevalol (a new non‐selective β‐blocker with β‐2 agonist activity). Plasma FFA concentrations during and after the infusions were measured using gas chromatography. A significant rise in total and individual FFAs was seen after 30 min of terbutaline infusion. This was most marked for oleic acid. Total and individual FFA concentrations also rose after 30 min of dilevalol infusion; this was only significant for oleic acid and was approximately 15% of the rise induced by terbutaline infusion. Placebo infusion did not cause any significant changes in FFA levels.