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THE INTERACTION OF ALCOHOL and ^‐BLOCKERS IN ARTERIAL HYPERTENSION
Author(s) -
Maheswaran R.,
Beevers D. G.,
Kendall M. J.,
Davies P.
Publication year - 1990
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1990.tb00404.x
Subject(s) - metoprolol , blood pressure , alcohol , medicine , placebo , supine position , anesthesia , antihypertensive drug , pharmacology , cardiology , chemistry , biochemistry , alternative medicine , pathology
Summary The acute effects of consuming alcohol after a single oral dose of 200 mg of metoprolol or placebo were examined in eight healthy men in a randomized, controlled study. Alcohol, in a dose of 0–75 g/kg body weight, did not abolish the antihypertensive effect of metoprolol upon supine systolic blood pressure. The interaction of alcohol with antihypertensive drugs requires further investigation as hypertensive patients who consume alcohol regularly are known to have less adequate blood pressure control.