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THEOPHYLLINE PLASMA CLEARANCE IN CRITICALLY ILL GERIATRIC PATIENTS RECEIVING TOTAL PARENTERAL NUTRITION and IN CONTROL PATIENTS
Author(s) -
Sangrador G.,
SanchezAlcaraz A.,
Ubeda R.,
Ibañez P.
Publication year - 1990
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1990.tb00385.x
Subject(s) - aminophylline , medicine , parenteral nutrition , theophylline , critically ill , plasma clearance , anesthesia , pharmacokinetics
Summary Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age > 65 years), distributed into two groups: Group I ( n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II ( n = 21) included patients admitted to the Internal Medicine Ward without TPN. All patients were treated with a constant intravenous infusion of aminophylline. Group I patients had a lower mean theophylline clearance of 0∣42 + 0∣23 ml/kg/min compared to Group II0∣64 ± 0∣24 ml/kg/min ( P = 0003).