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FACTORS INFLUENCING PRECIPITATION OF pH‐ADJUSTED BUPIVACAINE SOLUTIONS
Author(s) -
Bourget P.,
Bonhomme L.,
Benhamou D.
Publication year - 1990
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1990.tb00375.x
Subject(s) - bupivacaine , sodium bicarbonate , precipitation , bicarbonate , chemistry , sodium , anesthesia , medicine , organic chemistry , physics , meteorology
Summary Solutions of bupivacaine precipitate when bicarbonate is added. This limits the clinical use of pH‐adjustment in optimizing bupivacaine activity. In this study four different bupivacaine solutions were studied with the addition of sodium bicarbonate at 4° or 20°C. Bupivacaine concentrations remained unchanged after pH‐adjustment. Least crystallization was observed with bupivacaine solutions containing a small amount of sodium bicarbonate and stored at 4°C.