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CHEMICAL STABILITIES OF CEFUROXIME SODIUM AND METRONIDAZOLE IN AN ADMIXTURE FOR INTRAVENOUS INFUSION
Author(s) -
Barnes A. R.
Publication year - 1990
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1990.tb00374.x
Subject(s) - cefuroxime , metronidazole , chemistry , chromatography , kinetics , high performance liquid chromatography , chemical stability , reaction rate constant , sodium , zero order , sodium nitrite , first order , antibiotics , organic chemistry , biochemistry , mathematics , physics , quantum mechanics
Summary The chemical stabilities of cefuroxime sodium and metronidazole, when mixed together for intravenous infusion, were studied by high‐performance liquid chromatography (HPLC). The critical factor in the stability of the admixture was the degradation of cefuroxime sodium. At 25 o C, cefuroxime degraded by first‐order kinetics with a rate constant of 704 times 10 ‐2 /day and a t 90 (time to reach 90% of the original concentration) of 36 h. At 4 o C the rate constant was 5–23 times 10 ‐3 /day with a t 90 of 20 days, however, over the time‐scale studied, the kinetics approximated to zero‐order at this temperature. The mixture was also stable with respect to metronidazole, nitrite ion and appearance. A 7‐day storage life at 4°C can be given to the mixture.