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STABILITY OF SOLUTIONS OF HISTAMINE ACID PHOSPHATE AFTER STERILIZATION BY HEATING IN AN AUTOCLAVE
Author(s) -
McDonald C.,
Parkin J.E.,
Richardson C.A.,
Sweidan M.,
Lonergan D.,
Chan C.,
Cohen R.
Publication year - 1990
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1990.tb00354.x
Subject(s) - autoclave , sterilization (economics) , limiting , shelf life , histamine , phosphate , chemistry , filtration (mathematics) , medicine , chromatography , materials science , food science , mathematics , biochemistry , pharmacology , organic chemistry , engineering , business , mechanical engineering , foreign exchange market , statistics , finance , exchange rate
Summary Histamine acid phosphate (HAP) solutions are used in tests for asthma and also as positive controls in general allergenic testing. Previously these solutions have been sterilized, if at all, by nitration, thus limiting the shelf‐life of the preparation and introducing some degree of uncertainty in their use. It is shown here that HAP solutions can be sterilized successfully by heating in an autoclave with little degradation and that subsequent storage of autoclaved solutions indicates a minimum shelf‐life of 4 months.