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HPLC STUDIES ON THE DEGRADATION PROFILES OF GLUCOSE 5% SOLUTIONS SUBJECTED TO HEAT STERILIZATION IN A MICROPROCESSOR‐CONTROLLED AUTOCLAVE
Author(s) -
Cook A. P.,
MacLeod T. M.,
Appleton J. D.,
Fell A. F.
Publication year - 1989
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1989.tb00237.x
Subject(s) - sterilization (economics) , autoclave , degradation (telecommunications) , high performance liquid chromatography , chromatography , dry heat , chemistry , pulp and paper industry , materials science , organic chemistry , composite material , engineering , business , electrical engineering , finance , exchange rate , foreign exchange market
Summary A practically useful relationship between degradation and F 0 at various temperatures is given. This may be of value for identifying the most suitable sterilization conditions for a number of glucose products and other pharmaceuticals. It was found that autoclaving at a high temperature to a low final F 0 value gave the maximum product integrity.