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INVESTIGATIONS OF SOME PHYSICOCHEMICAL PROPERTIES OF HALOPERIDOL WHICH MAY AFFECT ITS ACTIVITY
Author(s) -
Öl¸er M.,
Hakyemez G.
Publication year - 1988
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1988.tb00203.x
Subject(s) - haloperidol , paraben , chemistry , solubility , chromatography , preservative , organic chemistry , medicine , dopamine
Summary Since the clinical response to haloperidol varies from individual to individual, an investigation was carried out to investigate some of the physicochemical properties of haloperidol which may affect its pharmacological activity. The stability of haloperidol in aqueous solutions containing 1% lactic acid, with or without 0·1% methyl paraben, was investigated. A colorimetric method based on a reaction between methyl orange and haloperidol was used. The samples (0·5mg/ml) were stored in glass and plastic containers at 25, 37, 50, 80 and 110°C for 9 months. The resulting data were analysed using principles of chemical kinetics. The shelf‐life of haloperidol solutions was estimated to be at least 4 years. Other physicochemical factors which can affect the pharmacological activity of haloperidol were investigated, namely its solubility and complex‐forming properties.