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CHEMICAL STABILITIES OF FAMOTIDINE AND RANITIDINE HYDROCHLORIDE IN INTRAVENOUS ADMIXTURES
Author(s) -
Gupta V. Das,
Parasrampuria J.,
Bethea C.
Publication year - 1988
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1988.tb00201.x
Subject(s) - famotidine , ranitidine , hydrochloride , chemistry , pharmacology , chromatography , medicine , organic chemistry
Summary The chemical stabilities of famotidine and ranitidine hydrochloride solutions in 5% dextrose and 0·9% sodium chloride injections have been studied using high‐performance liquid chromatographic methods (HPLC). Both the drugs were stable for at least 15 days (loss in potency of less than 10%) at 25°C and 63 days at 5°C. Both drugs were comparatively less stable in 5% dextrose injection than in 0·9% sodium chloride injection. The loss in the potency of phenol, which is added as a preservative to ranitidine hydrochloride injection, was significant in both the vehicles. However, the addition of preservative in a single dose vial is not considered necessary.