Premium
CHEMICAL STABILITY OF LIGNOCAINE (LIDOCAINE) AND ADRENALIN (EPINEPHRINE) IN pH‐ADJUSTED PARENTERAL SOLUTIONS
Author(s) -
Bonhomme L.,
Postaire E.,
Touratier S.,
Benhamou D.,
MartreSauvageon H.,
Preaux N.
Publication year - 1988
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1988.tb00190.x
Subject(s) - lidocaine , anesthesia , epinephrine , medicine
Summary Recent clinical studies have shown that alkalinizing lignocaine (lidocaine) solutions is an effective way of shortening the time of onset and increasing the duration of anaesthesia. However, alkalinizing lignocaine solutions raises the problem of the stability of these preparations. Moreover, the adrenalin usually associated with it is unstable in alkalinized solutions designed for peridural injection. This study was performed to define the range of pH over which lignocaine and adrenalin in commercial solution is stable. The results indicate that it is possible to alkalinize lignocaine solutions and that the solutions prepared are stable for at least 6 h.