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CHLOROQUINE ABSORPTION IN CHILDREN FROM POLYETHYLENE GLYCOL BASE SUPPOSITORIES
Author(s) -
Okor R. S.,
Nwankwo M. U.
Publication year - 1988
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1988.tb00184.x
Subject(s) - suppository , polyethylene glycol , pharmacokinetics , peg ratio , chloroquine , absorption (acoustics) , rectal administration , pharmacology , medicine , polyvinyl alcohol , chromatography , chemistry , malaria , immunology , biochemistry , materials science , organic chemistry , finance , composite material , economics
Summary Chloroquine phosphate (CP) has been formulated in a suppository base consisting of polyethylene glycol, PEG 1000 and PEG 6000 (7:3) with 0·5% polysorbate 80 included as an absorption promoter. Peak chloroquine blood levels in children (mean body weight 10 kg, age 21 months) were 0·67 ± 0·08 μg/ml (after 200 mg CP) and 1·06 ± 0·23 μg/ml (after 300 mg CP) following rectal administration of the suppositories. Prior to drug administration, the base level chloroquine was 0·30 ± 0·02 μg/ml. Elimination half lives calculated from the rapid phase of log concentration‐time curves were 3·3 h (after 200 mg CP) and 2·7 h (after 300 mg CP), respectively. Based on literature evidence the blood levels obtained with the 300 mg CP suppositories would be therapeutic in the management of malaria and rheumatoid disease.