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PRESCRIBING DIGOXIN IN GERIATRIC UNITS–EXERCISE AND REDISTRIBUTION OF DRUG
Author(s) -
Meghee S.,
Mooney C.,
Deshmukh A. A.,
O'Neill C. J. A.,
Bowes S.,
Royston J. P.,
Dobbs S. M.,
Dobbs R. J.
Publication year - 1987
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1987.tb00555.x
Subject(s) - digoxin , medicine , redistribution (election) , drug , serum concentration , drug interaction , pharmacokinetics , endocrinology , pharmacology , heart failure , politics , political science , law
SUMMARY In subjects capable of normal everyday activity, exercise has been shown to lower the serum digoxin concentration by increasing uptake into skeletal muscle. A randomized cross‐over study of the effect on the serum digoxin concentration of treatments consisting of rest for, or exercise during, 30 min was carried out in 20 elderly patients undergoing rehabilitation. In one patient exercise was associated with a marked (40%) reduction in the serum digoxin concentration. In the remainder there was a very small, but statistically significant, fall in concentration in the exercise as compared with the rest period. Unexpectedly low serum digoxin concentrations in in‐patients of geriatric units, may occasionally be an artefact due to temporary redistribution of digoxin.