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GLYCYRRHIZIN GEL AS A VEHICLE FOR IDOXURIDINE–I. CLINICAL INVESTIGATIONS
Author(s) -
Segal R.,
Pisanty S.
Publication year - 1987
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1987.tb00522.x
Subject(s) - glycyrrhizin , idoxuridine , medicine , permeation , pharmacology , nose , dermatology , chromatography , chemistry , virology , surgery , virus , biochemistry , membrane
SUMMARY The therapeutic efficacy of a new formulation that incorporates 0.2% IDU in glycyrrhizin gel has been tested on patients who suffer from herpes of the lips and nose. The preparation was significantly more effective than a commercial 0.5% IDU ointment. It reduced the healing time and produced an almost instantaneous relief from pain. The higher efficacy of the new preparation may be ascribed to the reported anti‐inflammatory and antiviral activities of glycyrrhizin together with an enhanced permeation of the IDU through the skin.