Premium
THE INFLUENCE OF BETA‐ADRENOCEPTOR BLOCKADE ON THE LIPOLYTIC RESPONSE TO EXERCISE
Author(s) -
Hall P. E.,
Smith S. R.,
Jack D. B.,
Kendall M. J.
Publication year - 1987
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1987.tb00514.x
Subject(s) - propranolol , metoprolol , pindolol , blockade , nadolol , placebo , endocrinology , medicine , chemistry , beta (programming language) , palmitic acid , fatty acid , receptor , biochemistry , alternative medicine , pathology , computer science , programming language
SUMMARY The influence of β‐adrenoceptor blockade on the free fatty acid (FFA) response during and after submaximal exercise was studied in a group of normal volunteers. The study showed that the exercise‐induced rise in serum FFA concentrations seen with placebo was reduced after pretreatment with propranolol. Furthermore, the palmitic, stearic, oleic and linoleic acid responses showed progressive attenuation with increasing doses of propranolol. Different β blockers were studied using comparablc doses: metoprolol and nadolol had little effect and produced FFA profiles that were similar to placebo whereas the changes on pindolol were comparable with those on propranolol.