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NOTE:CHEMICAL STABILITIES OF LIGNOCAINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN AQUEOUS SOLUTION
Author(s) -
Gupta V. Das,
Stewart K. R.
Publication year - 1986
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1986.tb00872.x
Subject(s) - lidocaine hydrochloride , phenylephrine , hydrochloride , chemistry , aqueous solution , chromatography , lidocaine , anesthesia , organic chemistry , medicine , blood pressure , radiology
SUMMARY The chemical stabilities of lignocaine hydrochloride (lidocaine hydrochloride) and phenylephrine hydrochloride in a combination aqueous solution have been determined using stability‐indicating high‐performance liquid chromatographic methods. The drugs did not interact and were stable for at least 66 days at room temperature. The pH value changed from 6.0 to 5.8 after 66 days but was still within the optimum pH range for the stabilities of lignocaine and phenylephrine.